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| Player | Team | Goals |
|---|---|---|
| Cristiano Ronaldo | Juventus | 29 |
| R. Lukaku | Inter | 24 |
| L. Muriel | Atalanta | 22 |
| D. Vlahović | Fiorentina | 21 |
| C. Immobile | Lazio | 20 |
| S. Nwankwo | Crotone | 20 |
| L. Insigne | Napoli | 19 |
| D. Berardi | Sassuolo | 17 |
| L. Martínez | Inter | 17 |
| João Pedro | Cagliari | 16 |
| D. Zapata | Atalanta | 15 |
| Z. Ibrahimović | AC Milan | 15 |
| H. Mkhitaryan | AS Roma | 13 |
| A. Belotti | Torino | 13 |
| F. Kessié | AC Milan | 13 |
| F. Quagliarella | Sampdoria | 13 |
| Morata | Juventus | 11 |
| R. Gosens | Atalanta | 11 |
| F. Caputo | Sassuolo | 11 |
| A. Rebić | AC Milan | 11 |
| H. Lozano | Napoli | 11 |
| M. Nzola | Spezia | 11 |
| M. Destro | Genoa | 11 |
| V. Osimhen | Napoli | 10 |
| Borja Mayoral | AS Roma | 10 |
| J. Veretout | AS Roma | 10 |
| R. De Paul | Udinese | 9 |
| D. Mertens | Napoli | 9 |
| R. Soriano | Bologna | 9 |
| Junior Messias | Crotone | 9 |