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| # | Team | P | W | D | L | Goals | Pts |
|---|---|---|---|---|---|---|---|
| 1 | Vancouver Whitecaps | 34 | 19 | 7 | 8 | 74:34 | 64 |
| 2 | FC Dallas | 33 | 15 | 10 | 8 | 59:50 | 55 |
| 3 | San Jose Earthquakes | 33 | 14 | 10 | 9 | 56:48 | 52 |
| 4 | St. Louis City SC | 33 | 14 | 9 | 10 | 58:48 | 51 |
| 5 | Houston Dynamo | 33 | 14 | 9 | 10 | 43:42 | 51 |
| 6 | LAFC | 33 | 12 | 11 | 10 | 51:38 | 47 |
| 7 | LA Galaxy | 33 | 11 | 11 | 11 | 49:55 | 44 |
| 8 | Portland Timbers | 33 | 12 | 7 | 14 | 60:61 | 43 |
| 9 | Colorado Rapids | 33 | 12 | 7 | 14 | 46:47 | 43 |
| 10 | Seattle Sounders | 33 | 11 | 10 | 12 | 42:45 | 43 |
| 11 | Real Salt Lake | 33 | 12 | 6 | 15 | 51:51 | 42 |
| 12 | Minnesota United FC | 33 | 10 | 11 | 12 | 53:57 | 41 |
| 13 | San Diego | 33 | 9 | 11 | 13 | 57:62 | 38 |
| 14 | Austin | 33 | 8 | 10 | 15 | 42:63 | 34 |
| 15 | Sporting Kansas City | 33 | 6 | 5 | 22 | 39:81 | 23 |
| # | Team | P | W | D | L | Goals | Pts |
|---|---|---|---|---|---|---|---|
| 1 | Nashville SC | 34 | 23 | 8 | 3 | 71:25 | 77 |
| 2 | Inter Miami | 34 | 16 | 12 | 6 | 80:59 | 60 |
| 3 | New England Revolution | 34 | 18 | 4 | 12 | 55:47 | 58 |
| 4 | Chicago Fire | 34 | 16 | 7 | 11 | 64:54 | 55 |
| 5 | Charlotte | 34 | 15 | 9 | 10 | 66:51 | 54 |
| 6 | Philadelphia Union | 34 | 14 | 8 | 12 | 66:52 | 50 |
| 7 | Columbus Crew | 34 | 14 | 5 | 15 | 59:52 | 47 |
| 8 | Orlando City SC | 34 | 13 | 7 | 14 | 63:78 | 46 |
| 9 | FC Cincinnati | 34 | 12 | 10 | 12 | 67:75 | 46 |
| 10 | New York Red Bulls | 34 | 12 | 6 | 16 | 48:62 | 42 |
| 11 | New York City FC | 34 | 10 | 12 | 12 | 49:45 | 42 |
| 12 | Toronto FC | 34 | 9 | 12 | 13 | 52:67 | 39 |
| 13 | Atlanta United FC | 34 | 9 | 6 | 19 | 43:60 | 33 |
| 14 | DC United | 34 | 7 | 12 | 15 | 39:61 | 33 |
| 15 | CF Montreal | 34 | 6 | 8 | 20 | 37:69 | 26 |
| Player | Team | Goals |
|---|---|---|
| L. Messi | Inter Miami | 26 |
| P. Musa | FC Dallas | 22 |
| S. Surridge | Nashville SC | 21 |
| B. White | Vancouver Whitecaps | 20 |
| M. Iloski | Philadelphia Union | 19 |