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| Player | Team | Goals |
|---|---|---|
| L. Messi | Inter Miami | 26 |
| P. Musa | FC Dallas | 22 |
| S. Surridge | Nashville SC | 21 |
| B. White | Vancouver Whitecaps | 20 |
| M. Iloski | Philadelphia Union | 19 |
| Denis Bouanga | LAFC | 18 |
| K. Yeboah | Minnesota United FC | 18 |
| Luis Suárez | Inter Miami | 17 |
| Kevin Denkey | FC Cincinnati | 17 |
| Preston Judd | San Jose Earthquakes | 17 |
| Guilherme Augusto | Houston Dynamo | 16 |
| H. Mukhtar | Nashville SC | 16 |
| N. Mercau | New York City FC | 16 |
| M. Ojeda | Orlando City SC | 16 |
| T. Baribo | DC United | 16 |
| I. Toklomati | Charlotte | 15 |
| P. Owusu | CF Montreal | 15 |
| S. Solans | Real Salt Lake | 15 |
| Evander | FC Cincinnati | 14 |
| Anders Dreyer | San Diego | 14 |
| Antoine Griezmann | Orlando City SC | 14 |
| Pep Biel | Charlotte | 13 |
| C. Gil | New England Revolution | 13 |
| M. Haile-Selassie | Chicago Fire | 13 |
| Bruno Damiani | Philadelphia Union | 13 |
| Julian Hall | New York Red Bulls | 13 |
| H. Cuypers | Chicago Fire | 13 |
| D. Turgeman | New England Revolution | 12 |
| K. Velde | Portland Timbers | 12 |
| M. Ingvartsen | San Diego | 12 |