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| Player | Team | Goals |
|---|---|---|
| Camilo Sanvezzo | Whitecaps | 22 |
| M. Di Vaio | CF Montreal | 20 |
| R. Keane | LA Galaxy | 16 |
| M. Magee | Chicago Fire | 15 |
| Á. Saborío | Real Salt Lake | 13 |
| D. Fagúndez | New England Revolution | 13 |
| D. Oduro | Columbus Crew | 13 |
| J. McInerney | Philadelphia Union | 12 |
| T. Cahill | New York Red Bulls | 12 |
| B. Pérez | FC Dallas | 11 |
| C. Bieler | Sporting Kansas City | 11 |
| C. Wondolowski | San Jose Earthquakes | 11 |
| D. Váleri | Portland Timbers | 11 |
| E. Johnson | Seattle Sounders | 11 |
| F. Higuaín | Columbus Crew | 11 |
| W. Johnson | Portland Timbers | 11 |
| C. Casey | Philadelphia Union | 10 |
| D. Brown | Colorado Rapids | 10 |
| D. Nagbe | Portland Timbers | 10 |
| L. Donovan | LA Galaxy | 10 |
| R. Johnson | Portland Timbers | 10 |
| T. Henry | New York Red Bulls | 10 |
| W. Bruin | Houston Dynamo | 10 |
| F. Espíndola | New York Red Bulls | 9 |
| G. Barnes | Houston Dynamo | 9 |
| J. Morales | Real Salt Lake | 9 |
| K. Miller | Whitecaps | 8 |
| K. Rowe | New England Revolution | 8 |
| L. Neagle | Seattle Sounders | 8 |
| O. Martins | Seattle Sounders | 8 |