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| Player | Team | Goals |
|---|---|---|
| B. Wright-Phillips | New York Red Bulls | 30 |
| D. Dwyer | Sporting Kansas City | 23 |
| R. Keane | LA Galaxy | 21 |
| L. Nguyen | New England Revolution | 20 |
| G. Zardes | LA Galaxy | 17 |
| O. Martins | Seattle Sounders | 17 |
| C. Dempsey | Seattle Sounders | 16 |
| E. Torres | Chivas USA | 15 |
| C. Wondolowski | San Jose Earthquakes | 14 |
| J. Plata | Real Salt Lake | 13 |
| L. Donovan | LA Galaxy | 13 |
| F. Higuaín | Columbus Crew | 12 |
| S. Le Toux | Philadelphia Union | 12 |
| B. Pérez | FC Dallas | 11 |
| D. Váleri | Portland Timbers | 11 |
| E. Finlay | Columbus Crew | 11 |
| F. Castillo | FC Dallas | 11 |
| F. Espíndola | DC United | 11 |
| G. Barnes | Houston Dynamo | 11 |
| J. Defoe | Toronto FC | 11 |
| L. Silva | DC United | 11 |
| D. Brown | Colorado Rapids | 10 |
| Michel | FC Dallas | 10 |
| M. Urruti | Portland Timbers | 10 |
| P. Morales | Whitecaps | 10 |
| T. Henry | New York Red Bulls | 10 |
| W. Bruin | Houston Dynamo | 10 |
| F. Adi | Portland Timbers | 9 |
| J. Meram | Columbus Crew | 9 |
| J. Morales | Real Salt Lake | 9 |