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| Player | Team | Goals |
|---|---|---|
| K. Kamara | Columbus Crew | 26 |
| S. Giovinco | Toronto FC | 21 |
| R. Keane | LA Galaxy | 20 |
| B. Wright-Phillips | New York Red Bulls | 18 |
| David Villa | New York City FC | 18 |
| F. Adi | Portland Timbers | 18 |
| C. Larin | Orlando City SC | 17 |
| C. Wondolowski | San Jose Earthquakes | 16 |
| O. Martins | Seattle Sounders | 15 |
| E. Finlay | Columbus Crew | 13 |
| J. Altidore | Toronto FC | 13 |
| C. Dempsey | Seattle Sounders | 12 |
| D. Drogba | CF Montreal | 12 |
| D. Dwyer | Sporting Kansas City | 12 |
| K. Németh | Sporting Kansas City | 11 |
| Chris Rolfe | DC United | 11 |
| W. Bruin | Houston Dynamo | 11 |
| B. Feilhaber | Sporting Kansas City | 10 |
| I. Piatti | CF Montreal | 10 |
| F. Castillo | FC Dallas | 10 |
| L. Sam | New York Red Bulls | 10 |
| C. Davies | New England Revolution | 10 |
| O. Rivero | Whitecaps | 10 |
| D. Accam | Chicago Fire | 10 |
| F. Higuaín | Columbus Crew | 9 |
| Kaká | Orlando City SC | 9 |
| M. Grella | New York Red Bulls | 9 |
| C. Sapong | Philadelphia Union | 9 |
| M. Díaz | FC Dallas | 8 |
| S. Klještan | New York Red Bulls | 8 |