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| Player | Team | Goals |
|---|---|---|
| David Villa | New York City FC | 24 |
| N. Nikolić | Chicago Fire | 24 |
| D. Váleri | Portland Timbers | 21 |
| O. Kamara | Columbus Crew | 19 |
| B. Wright-Phillips | New York Red Bulls | 19 |
| J. Martínez | Atlanta United FC | 19 |
| S. Giovinco | Toronto FC | 17 |
| J. Altidore | Toronto FC | 17 |
| I. Piatti | CF Montreal | 17 |
| C. Sapong | Philadelphia Union | 16 |
| C. Dempsey | Seattle Sounders | 15 |
| D. Accam | Chicago Fire | 14 |
| F. Montero | Vancouver Whitecaps | 14 |
| Justin Meram | Columbus Crew | 14 |
| C. Ramírez | Minnesota United FC | 14 |
| D. Royer | New York Red Bulls | 14 |
| E. Torres | Houston Dynamo | 14 |
| R. Alessandrini | LA Galaxy | 13 |
| H. Villalba | Atlanta United FC | 13 |
| C. Wondolowski | San Jose Earthquakes | 13 |
| W. Bruin | Seattle Sounders | 13 |
| K. Kamara | New England Revolution | 12 |
| M. Urruti | FC Dallas | 12 |
| C. Larin | Orlando City SC | 12 |
| L. Nguyen | New England Revolution | 11 |
| M. Manotas | Houston Dynamo | 11 |
| A. Elis | Houston Dynamo | 11 |
| Víctor Vázquez | Toronto FC | 10 |
| J. Harrison | New York City FC | 10 |
| F. Adi | Portland Timbers | 10 |