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| Player | Team | Goals |
|---|---|---|
| C. Vela | LAFC | 35 |
| Zlatan Ibrahimović | LA Galaxy | 32 |
| Josef Martínez | Atlanta United FC | 28 |
| D. Rossi | LAFC | 18 |
| Kacper Przybyłko | Philadelphia Union | 15 |
| R. Ruidíaz | Seattle Sounders | 15 |
| Héber | New York City FC | 15 |
| C. Wondolowski | San Jose Earthquakes | 15 |
| Alejandro Pozuelo | Toronto FC | 14 |
| K. Kamara | Colorado Rapids | 14 |
| M. Manotas | Houston Dynamo | 13 |
| Jordan Morris | Seattle Sounders | 13 |
| G. Zardes | Columbus Crew | 13 |
| C.J. Sapong | Chicago Fire | 13 |
| Jozy Altidore | Toronto FC | 12 |
| Nani | Orlando City SC | 12 |
| A. Mitriță | New York City FC | 12 |
| Felipe Gutiérrez | Sporting Kansas City | 12 |
| N. Nikolić | Chicago Fire | 12 |
| Daniel Royer | New York Red Bulls | 11 |
| W. Rooney | DC United | 11 |
| Valentín Castellanos | New York City FC | 11 |
| D. Rubio | Colorado Rapids | 11 |
| Pedro Santos | Columbus Crew | 11 |
| Brian Fernández | Portland Timbers | 11 |
| Jeremy Ebobisse | Portland Timbers | 11 |
| Carles Gil | New England Revolution | 10 |
| Darwin Quintero | Minnesota United FC | 10 |
| A. Rusnák | Real Salt Lake | 10 |
| Tesho Akindele | Orlando City SC | 10 |