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| Player | Team | Goals |
|---|---|---|
| D. Rossi | LAFC | 16 |
| Zardes G. | Columbus Crew | 15 |
| R. Ruidíaz | Seattle Sounders | 14 |
| K. Molino | Minnesota United FC | 13 |
| R. Berič | Chicago Fire | 12 |
| R. Morris J. + Ruidiaz | Seattle Sounders | 11 |
| S. Santos | Philadelphia Union | 11 |
| C. Mueller | Orlando City SC | 10 |
| R. Lod | Minnesota United FC | 10 |
| C. Pavón | LA Galaxy | 10 |
| Pozuelo | Toronto FC | 9 |
| D. Váleri | Portland Timbers | 9 |
| B. Wright-Phillips | LAFC | 9 |
| Nani | Orlando City SC | 9 |
| R. Quioto | CF Montreal | 9 |
| J. Ebobisse | Portland Timbers | 9 |
| C. Wondolowski | San Jose Earthquakes | 9 |
| D. Kreilach | Real Salt Lake | 9 |
| A. Akinola | Toronto FC | 9 |
| N. Lodeiro | Seattle Sounders | 8 |
| Santos P. | Columbus Crew | 8 |
| K. Przybyłko | Philadelphia Union | 8 |
| D. Dike | Orlando City SC | 8 |
| G. Bou | New England Revolution | 8 |
| J. Niezgoda | Portland Timbers | 8 |
| Zelarayan L. | Columbus Crew | 8 |
| T. Bunbury | New England Revolution | 8 |
| C. Quintero | Houston Dynamo | 7 |
| A. Pulido | Sporting Kansas City | 7 |
| J. Medina | New York City FC | 7 |