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| # | Team | P | W | D | L | Goals | Pts |
|---|---|---|---|---|---|---|---|
| 1 | New England Revolution | 34 | 22 | 7 | 5 | 65:41 | 73 |
| 2 | Philadelphia Union | 34 | 14 | 12 | 8 | 48:35 | 54 |
| 3 | Nashville SC | 34 | 12 | 18 | 4 | 55:33 | 54 |
| 4 | New York City FC | 34 | 14 | 9 | 11 | 56:36 | 51 |
| 5 | Atlanta United FC | 34 | 13 | 12 | 9 | 45:37 | 51 |
| 6 | Orlando City SC | 34 | 13 | 12 | 9 | 50:48 | 51 |
| 7 | New York Red Bulls | 34 | 13 | 9 | 12 | 39:33 | 48 |
| 8 | DC United | 34 | 14 | 5 | 15 | 56:54 | 47 |
| 9 | Columbus Crew | 34 | 13 | 8 | 13 | 46:45 | 47 |
| 10 | CF Montreal | 34 | 12 | 10 | 12 | 46:44 | 46 |
| 11 | Inter Miami | 34 | 12 | 5 | 17 | 36:53 | 41 |
| 12 | Chicago Fire | 34 | 9 | 7 | 18 | 36:54 | 34 |
| 13 | Toronto FC | 34 | 6 | 10 | 18 | 39:66 | 28 |
| 14 | FC Cincinnati | 34 | 4 | 8 | 22 | 37:74 | 20 |
| # | Team | P | W | D | L | Goals | Pts |
|---|---|---|---|---|---|---|---|
| 1 | Colorado Rapids | 34 | 17 | 10 | 7 | 51:35 | 61 |
| 2 | Seattle Sounders | 34 | 17 | 9 | 8 | 53:33 | 60 |
| 3 | Sporting Kansas City | 34 | 17 | 7 | 10 | 58:40 | 58 |
| 4 | Portland Timbers | 34 | 17 | 4 | 13 | 56:52 | 55 |
| 5 | Minnesota United FC | 34 | 13 | 10 | 11 | 42:44 | 49 |
| 6 | Vancouver Whitecaps | 34 | 12 | 13 | 9 | 45:45 | 49 |
| 7 | Real Salt Lake | 34 | 14 | 6 | 14 | 55:54 | 48 |
| 8 | LA Galaxy | 34 | 13 | 9 | 12 | 50:54 | 48 |
| 9 | LAFC | 34 | 12 | 9 | 13 | 53:51 | 45 |
| 10 | San Jose Earthquakes | 34 | 10 | 11 | 13 | 46:54 | 41 |
| 11 | FC Dallas | 34 | 7 | 12 | 15 | 47:56 | 33 |
| 12 | Austin | 34 | 9 | 4 | 21 | 35:56 | 31 |
| 13 | Houston Dynamo | 34 | 6 | 12 | 16 | 36:54 | 30 |
| Player | Team | Goals |
|---|---|---|
| V. Castellanos | New York City FC | 23 |
| H. Mukhtar | Nashville SC | 19 |
| O. Kamara | DC United | 19 |
| R. Ruidíaz | Seattle Sounders | 18 |
| D. Kreilach | Real Salt Lake | 17 |