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| Player | Team | Goals |
|---|---|---|
| J. Martínez | Atlanta United FC | 35 |
| Z. Ibrahimović | LA Galaxy | 22 |
| B. Wright-Phillips | New York Red Bulls | 20 |
| G. Zardes | Columbus Crew | 20 |
| M. Manotas | Houston Dynamo | 19 |
| I. Piatti | CF Montreal | 16 |
| David Villa | New York City FC | 15 |
| D. Kreilach | Real Salt Lake | 15 |
| N. Nikolić | Chicago Fire | 15 |
| D. Váleri | Portland Timbers | 14 |
| C. Vela | LAFC | 14 |
| D. Salloi | Sporting Kansas City | 14 |
| K. Kamara | Vancouver Whitecaps | 14 |
| O. Kamara | LA Galaxy | 14 |
| M. Almirón | Atlanta United FC | 13 |
| S. Blanco | Portland Timbers | 13 |
| S. Giovinco | Toronto FC | 13 |
| D. Royer | New York Red Bulls | 13 |
| R. Ruidíaz | Seattle Sounders | 13 |
| D. Dwyer | Orlando City SC | 13 |
| C. Penilla | New England Revolution | 12 |
| D. Rossi | LAFC | 12 |
| W. Rooney | DC United | 12 |
| A. Diomande | LAFC | 12 |
| A. Katai | Chicago Fire | 12 |
| D. Hoesen | San Jose Earthquakes | 12 |
| Ismael Tajouri | New York City FC | 12 |
| C. Quintero | Minnesota United FC | 11 |
| A. Elis | Houston Dynamo | 11 |
| R. Alessandrini | LA Galaxy | 11 |