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| # | Team | P | W | D | L | Goals | Pts |
|---|---|---|---|---|---|---|---|
| 1 | Philadelphia Union | 34 | 19 | 10 | 5 | 72:26 | 67 |
| 2 | CF Montreal | 34 | 20 | 5 | 9 | 63:50 | 65 |
| 3 | New York City FC | 34 | 16 | 7 | 11 | 57:41 | 55 |
| 4 | New York Red Bulls | 34 | 15 | 8 | 11 | 50:41 | 53 |
| 5 | FC Cincinnati | 34 | 12 | 13 | 9 | 64:56 | 49 |
| 6 | Inter Miami | 34 | 14 | 6 | 14 | 47:56 | 48 |
| 7 | Orlando City SC | 34 | 14 | 6 | 14 | 44:53 | 48 |
| 8 | Columbus Crew | 34 | 10 | 16 | 8 | 46:41 | 46 |
| 9 | Charlotte | 34 | 13 | 3 | 18 | 44:52 | 42 |
| 10 | New England Revolution | 34 | 10 | 12 | 12 | 47:50 | 42 |
| 11 | Atlanta United FC | 34 | 10 | 10 | 14 | 48:54 | 40 |
| 12 | Chicago Fire | 34 | 10 | 9 | 15 | 39:48 | 39 |
| 13 | Toronto FC | 34 | 9 | 7 | 18 | 49:66 | 34 |
| 14 | DC United | 34 | 7 | 6 | 21 | 36:71 | 27 |
| # | Team | P | W | D | L | Goals | Pts |
|---|---|---|---|---|---|---|---|
| 1 | LAFC | 34 | 21 | 4 | 9 | 66:38 | 67 |
| 2 | Austin | 34 | 16 | 8 | 10 | 65:49 | 56 |
| 3 | FC Dallas | 34 | 14 | 11 | 9 | 48:37 | 53 |
| 4 | LA Galaxy | 34 | 14 | 8 | 12 | 58:51 | 50 |
| 5 | Nashville SC | 34 | 13 | 11 | 10 | 52:41 | 50 |
| 6 | Minnesota United FC | 34 | 14 | 6 | 14 | 48:51 | 48 |
| 7 | Real Salt Lake | 34 | 12 | 11 | 11 | 43:45 | 47 |
| 8 | Portland Timbers | 34 | 11 | 13 | 10 | 53:53 | 46 |
| 9 | Vancouver Whitecaps | 34 | 12 | 7 | 15 | 40:57 | 43 |
| 10 | Colorado Rapids | 34 | 11 | 10 | 13 | 46:57 | 43 |
| 11 | Seattle Sounders | 34 | 12 | 5 | 17 | 47:46 | 41 |
| 12 | Sporting Kansas City | 34 | 11 | 7 | 16 | 42:54 | 40 |
| 13 | Houston Dynamo | 34 | 10 | 6 | 18 | 43:56 | 36 |
| 14 | San Jose Earthquakes | 34 | 8 | 11 | 15 | 52:69 | 35 |
| Player | Team | Goals |
|---|---|---|
| S. Driussi | Austin | 26 |
| D. Gazdag | Philadelphia Union | 24 |
| H. Mukhtar | Nashville SC | 23 |
| B. Vázquez | FC Cincinnati | 19 |
| J. Ferreira | FC Dallas | 19 |