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| Player | Team | Goals |
|---|---|---|
| S. Driussi | Austin | 26 |
| D. Gazdag | Philadelphia Union | 24 |
| H. Mukhtar | Nashville SC | 23 |
| B. Vázquez | FC Cincinnati | 19 |
| J. Ferreira | FC Dallas | 19 |
| Brenner | FC Cincinnati | 18 |
| C. Arango | LAFC | 18 |
| J. Hernández | LA Galaxy | 18 |
| J. Ebobisse | San Jose Earthquakes | 17 |
| D. Rubio | Colorado Rapids | 16 |
| G. Higuaín | Inter Miami | 16 |
| J. Carranza | Philadelphia Union | 15 |
| R. Quioto | CF Montreal | 15 |
| L. Morgan | New York Red Bulls | 15 |
| M. Uhre | Philadelphia Union | 13 |
| S. Ferreira | Houston Dynamo | 13 |
| V. Castellanos | New York City FC | 13 |
| C. Vela | LAFC | 12 |
| E. Reynoso | Minnesota United FC | 12 |
| D. Joveljić | LA Galaxy | 12 |
| T. Fountas | DC United | 12 |
| L. Acosta | FC Cincinnati | 11 |
| D. Mihailovic | CF Montreal | 11 |
| E. Kara | Orlando City SC | 11 |
| L. Campana | Inter Miami | 11 |
| S. Córdova | Real Salt Lake | 11 |
| L. Zelarayán | Columbus Crew | 10 |
| P. Arriola | FC Dallas | 10 |
| K. Świderski | Charlotte | 10 |
| D. Asprilla | Portland Timbers | 10 |