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| Player | Team | Goals |
|---|---|---|
| L. Messi | Inter Miami | 35 |
| D. Bouanga | LAFC | 26 |
| S. Surridge | Nashville SC | 25 |
| A. Dreyer | San Diego | 23 |
| T. Allende | Inter Miami | 20 |
| P. Musa | FC Dallas | 19 |
| A. Martinez | New York City FC | 19 |
| H. Cuypers | Chicago Fire | 19 |
| Evander | FC Cincinnati | 18 |
| T. Baribo | Philadelphia Union | 18 |
| B. White | Vancouver Whitecaps | 18 |
| D. Joveljic | Sporting Kansas City | 18 |
| H. Mukhtar | Nashville SC | 17 |
| E. M. Choupo-Moting | New York Red Bulls | 17 |
| M. Ojeda | Orlando City SC | 16 |
| D. Rossi | Columbus Crew | 16 |
| D. Musovski | Seattle Sounders | 16 |
| K. Denkey | FC Cincinnati | 16 |
| P. Zinckernagel | Chicago Fire | 15 |
| J. Martinez | San Jose Earthquakes | 14 |
| C. Arango | San Jose Earthquakes | 13 |
| P. Owusu | CF Montreal | 13 |
| A. Rusnak | Seattle Sounders | 12 |
| M. Pasalic | Orlando City SC | 12 |
| I. Toklomati | Charlotte | 12 |
| Son Heung-Min | LAFC | 12 |
| Rafael Navarro | Colorado Rapids | 12 |
| H. Lozano | San Diego | 11 |
| H. Wolf | New York City FC | 11 |
| E. Forsberg | New York Red Bulls | 11 |