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| # | Team | P | W | D | L | Goals | Pts |
|---|---|---|---|---|---|---|---|
| 1 | FC Cincinnati | 34 | 20 | 9 | 5 | 57:39 | 69 |
| 2 | Orlando City SC | 34 | 18 | 9 | 7 | 55:39 | 63 |
| 3 | Columbus Crew | 34 | 16 | 9 | 9 | 67:46 | 57 |
| 4 | Philadelphia Union | 34 | 15 | 10 | 9 | 57:41 | 55 |
| 5 | New England Revolution | 34 | 15 | 10 | 9 | 58:46 | 55 |
| 6 | Atlanta United FC | 34 | 13 | 12 | 9 | 66:53 | 51 |
| 7 | Nashville SC | 34 | 13 | 10 | 11 | 39:32 | 49 |
| 8 | New York Red Bulls | 34 | 11 | 10 | 13 | 36:39 | 43 |
| 9 | Charlotte | 34 | 10 | 13 | 11 | 45:52 | 43 |
| 10 | CF Montreal | 34 | 12 | 5 | 17 | 36:52 | 41 |
| 11 | New York City FC | 34 | 9 | 14 | 11 | 35:39 | 41 |
| 12 | DC United | 34 | 10 | 10 | 14 | 45:49 | 40 |
| 13 | Chicago Fire | 34 | 10 | 10 | 14 | 39:51 | 40 |
| 14 | Inter Miami | 34 | 9 | 7 | 18 | 41:54 | 34 |
| 15 | Toronto FC | 34 | 4 | 10 | 20 | 26:59 | 22 |
| # | Team | P | W | D | L | Goals | Pts |
|---|---|---|---|---|---|---|---|
| 1 | St. Louis City SC | 34 | 17 | 5 | 12 | 62:45 | 56 |
| 2 | Seattle Sounders | 34 | 14 | 11 | 9 | 41:32 | 53 |
| 3 | LAFC | 34 | 14 | 10 | 10 | 54:39 | 52 |
| 4 | Houston Dynamo | 34 | 14 | 9 | 11 | 51:38 | 51 |
| 5 | Real Salt Lake | 34 | 14 | 8 | 12 | 48:50 | 50 |
| 6 | Vancouver Whitecaps | 34 | 12 | 12 | 10 | 55:48 | 48 |
| 7 | FC Dallas | 34 | 11 | 13 | 10 | 41:37 | 46 |
| 8 | Sporting Kansas City | 34 | 12 | 8 | 14 | 48:51 | 44 |
| 9 | San Jose Earthquakes | 34 | 10 | 14 | 10 | 39:43 | 44 |
| 10 | Portland Timbers | 34 | 11 | 10 | 13 | 46:58 | 43 |
| 11 | Minnesota United FC | 34 | 10 | 11 | 13 | 46:51 | 41 |
| 12 | Austin | 34 | 10 | 9 | 15 | 49:55 | 39 |
| 13 | LA Galaxy | 34 | 8 | 12 | 14 | 51:67 | 36 |
| 14 | Colorado Rapids | 34 | 5 | 12 | 17 | 26:54 | 27 |
| Player | Team | Goals |
|---|---|---|
| D. Bouanga | LAFC | 25 |
| J. Hernández | Columbus Crew | 21 |
| L. Acosta | FC Cincinnati | 20 |
| G. Giakoumakis | Atlanta United FC | 19 |
| B. White | Vancouver Whitecaps | 16 |