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| Player | Team | Goals |
|---|---|---|
| D. Bouanga | LAFC | 25 |
| J. Hernández | Columbus Crew | 21 |
| L. Acosta | FC Cincinnati | 20 |
| G. Giakoumakis | Atlanta United FC | 19 |
| B. White | Vancouver Whitecaps | 16 |
| H. Mukhtar | Nashville SC | 15 |
| D. Gazdag | Philadelphia Union | 15 |
| J. Carranza | Philadelphia Union | 14 |
| A. Pulido | Sporting Kansas City | 14 |
| C. Benteke | DC United | 14 |
| F. Torres | Orlando City SC | 14 |
| C. Espinoza | San Jose Earthquakes | 13 |
| J. Ferreira | FC Dallas | 13 |
| D. McGuire | Orlando City SC | 13 |
| A. Bassi | Houston Dynamo | 13 |
| J. Morris | Seattle Sounders | 13 |
| T. Almada | Atlanta United FC | 12 |
| K. Świderski | Charlotte | 12 |
| R. Gauld | Vancouver Whitecaps | 11 |
| Carles Gil | New England Revolution | 11 |
| S. Driussi | Austin | 11 |
| D. Sallói | Sporting Kansas City | 10 |
| L. Zelarayán | Columbus Crew | 10 |
| M. Uhre | Philadelphia Union | 10 |
| C. Ramírez | Columbus Crew | 10 |
| B. Vázquez | FC Cincinnati | 10 |
| J. Ebobisse | San Jose Earthquakes | 10 |
| João Klauss | St. Louis City SC | 10 |
| N. Gioacchini | St. Louis City SC | 10 |
| T. Pukki | Minnesota United FC | 10 |