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| # | Team | P | W | D | L | Goals | Pts |
|---|---|---|---|---|---|---|---|
| 1 | Inter Miami | 34 | 22 | 8 | 4 | 79:49 | 74 |
| 2 | Columbus Crew | 34 | 19 | 9 | 6 | 72:40 | 66 |
| 3 | FC Cincinnati | 34 | 18 | 5 | 11 | 58:48 | 59 |
| 4 | Orlando City SC | 34 | 15 | 7 | 12 | 59:50 | 52 |
| 5 | Charlotte | 34 | 14 | 9 | 11 | 46:37 | 51 |
| 6 | New York City FC | 34 | 14 | 8 | 12 | 54:49 | 50 |
| 7 | New York Red Bulls | 34 | 11 | 14 | 9 | 55:50 | 47 |
| 8 | CF Montreal | 34 | 11 | 10 | 13 | 48:64 | 43 |
| 9 | Atlanta United FC | 34 | 10 | 10 | 14 | 46:49 | 40 |
| 10 | DC United | 34 | 10 | 10 | 14 | 52:70 | 40 |
| 11 | Toronto FC | 34 | 11 | 4 | 19 | 40:61 | 37 |
| 12 | Philadelphia Union | 34 | 9 | 10 | 15 | 62:55 | 37 |
| 13 | Nashville SC | 34 | 9 | 9 | 16 | 38:54 | 36 |
| 14 | New England Revolution | 34 | 9 | 4 | 21 | 37:74 | 31 |
| 15 | Chicago Fire | 34 | 7 | 9 | 18 | 40:62 | 30 |
| # | Team | P | W | D | L | Goals | Pts |
|---|---|---|---|---|---|---|---|
| 1 | LAFC | 34 | 19 | 7 | 8 | 63:43 | 64 |
| 2 | LA Galaxy | 34 | 19 | 7 | 8 | 69:50 | 64 |
| 3 | Real Salt Lake | 34 | 16 | 11 | 7 | 65:48 | 59 |
| 4 | Seattle Sounders | 34 | 16 | 9 | 9 | 51:35 | 57 |
| 5 | Houston Dynamo | 34 | 15 | 9 | 10 | 47:39 | 54 |
| 6 | Minnesota United FC | 34 | 15 | 7 | 12 | 58:49 | 52 |
| 7 | Colorado Rapids | 34 | 15 | 5 | 14 | 61:60 | 50 |
| 8 | Vancouver Whitecaps | 34 | 13 | 8 | 13 | 52:49 | 47 |
| 9 | Portland Timbers | 34 | 12 | 11 | 11 | 65:56 | 47 |
| 10 | Austin | 34 | 11 | 9 | 14 | 39:48 | 42 |
| 11 | FC Dallas | 34 | 11 | 8 | 15 | 54:56 | 41 |
| 12 | St. Louis City SC | 34 | 8 | 13 | 13 | 50:63 | 37 |
| 13 | Sporting Kansas City | 34 | 8 | 7 | 19 | 51:66 | 31 |
| 14 | San Jose Earthquakes | 34 | 6 | 3 | 25 | 41:78 | 21 |
| Player | Team | Goals |
|---|---|---|
| C. Benteke | DC United | 23 |
| L. Messi | Inter Miami | 21 |
| D. Bouanga | LAFC | 21 |
| L. Suárez | Inter Miami | 21 |
| D. Joveljić | LA Galaxy | 21 |